基因编辑婴儿23个疑问，贺建奎回答了什么、回避了什么丨钛媒体万字实录

Team member went to talk to the volunteer first for 2 hours, and then after 1 month, the volunteers came to Shenzhen and I personally took them to another professor and gave them informed consent.

接着问：所以你直接参与了?

So you were directly involved?

贺建奎：我参与了。同时，我也告诉了他们脱靶等信息。

I was involved. Also, I brought them the information about off-targets and so on.

问题五：你是如何招募到这些夫妇参与研究的？是通过私人关系吗？你的机构发布公告了吗？如何招募这些特殊的夫妇?

How did you recruit these couples into your study? Was it done by personal connections? Did your institution put out a release? How was recruitment done of these particular couples?

贺建奎：这是由一个艾滋病志愿者组织平台招募的。

It was by an HIV/AIDS volunteer group.

（大会主席David Baltimore发表了一段声明）

问题六：同意David Baltimore所说的，感谢你在如此不同寻常的境况下还来到这里。首先，我认为这些女孩没有未被满足的医疗需求。父亲是HIV阳性，母亲是HIV阴性。你已经对精子进行了清洗，因此已经可以产生未受感染的胚胎，这些胚胎可以孕育出未受感染的婴儿。

你能描述一下什么是未被满足的医疗需求吗，不是一般意义上的我们所知道的HIV。但什么是对这些病人来说尤为重要的未被满足的医疗需求？其次，你用病人而不是科学家、医生和伦理学家所做的决定，证明了植入这些胚胎以创造人类妊娠的关键决定是合理的。作为科学家、医生和独立团体，我们有什么责任为病人做出决定，而不是让他们自己做出决定？非常感谢。

I'd like to echo David Baltimore's comments thanking you for coming here under some unusual circumstances. First, I don't see the unmet medical need for these girls. The father is HIV positive and the mother is HIV negative. You already did sperm washing, and thus you already could generate uninfected embryos that could give rise to uninfected babies. Could you describe what is the unmet medical need, not of HIV in general which I think we all appreciate, but what is the unmet medical need for these patients in particular? Second, you justified the critical decision of implanting these embryos to create a human pregnancy with the decisions made by the patients rather than made by the scientists, doctors and ethicists. Can you comment on what is our responsibility as scientists and doctors and independent communities to make that decision for the patients rather than allowing them to make that decision seemingly on their own? Thank you very much.

贺建奎：第一个问题是CCR5是否是一个未被满足的医疗需求。我相信这不仅仅是针对这个案例，而是针对千百万儿童。他们需要这种保护。目前还没有艾滋病毒疫苗。我个人接触过一些艾滋病患者，那里30%的村民感染了艾滋病。他们甚至不得不把孩子交给亲戚和叔叔抚养，只是为了防止潜在的传播。对于这个具体的案例，我感到很自豪。实际上是我感到最自豪的，因为他们对生活失去了希望。但有了这种保护，他发了一条信息，说他将努力工作，赚钱，并照顾他的两个女儿和他的妻子一辈子。

The first question was whether CCR5 is an unmet medical need. I actually believe that this is not just for this case, but for millions of children. They need this protection. HIV vaccine is not available. I personally experience with some people in AIDS where 30% of a village people are infected. They even have to give their children to relatives and uncles to raise just to prevent potential transmission. For this specific case, I feel proud. I feel proudest, because they had lost hope for life. But with this protection, he sent a message saying he will work hard, earn money, and take care of his two daughters and his wife for this life.

问题七：在我们讨论第二个问题之前，你说过没有其他植入。需要说明的是，你的临床试验中是否还有其他进行中的基因组编辑?

Before we get to the second question, you said there has been no other implantations. Just to be clear, are there any other pregnancies with genome editing as part of your clinical trials?

贺建奎：还有一个，另一个还在怀孕早期阶段。

There is another one, another potential pregnancy.

接着问：你说的是早期？所以是生化妊娠阶段？

You said early stage? So chemical pregnancy?

贺建奎：是的。

Yes.

问题八：我有两个关于伦理的问题。你能不能放慢一点谈谈你说过的制度伦理过程。第二部分是展望未来——你如何理解你对这些孩子的责任？最后一张幻灯片显示你将进行后续治疗。你对未来有什么责任？

I have a two-part ethical question. Could you slow down a little bit and talk about the institutional ethics process that you said you went through. Looking to the past. The second part is looking to the future- how do you understand your responsibility to these children? Your last slide indicated that you would be doing follow-up treatment. What is your responsibility towards the future as well?

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